Far and away the most useful PowerUp is the colour organiser you get by making the Cyan balls your third in a row. Try to get to the stage where you have just three colours left, any other two and the Cyan. Then kill Cyan third and last. The newly arriving string will then be sorted into colours straight away and then you can start reducing to just the three sets again, including Cyan. Be prepared just to throw away the odd ball so that you reset the three-in-a row counter when just three colours remain.

If in the thinning down process you trigger other Power Ups, like the Sandstorm, the Net or the Scorpion, DO NOT catch them. They will destroy your carefully preserved Cyan ball pair which must the hte last shot of each string.